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徐炳聪,谢穗峰,蔡莉丽.喹硫平联合奥氮平治疗精神分裂症的临床研究[J].中国医药科学,2019,(16):100-102        基金项目:
喹硫平联合奥氮平治疗精神分裂症的临床研究
Clinical study of quetiapine combined with olanzapine in the treatment of schizophrenia
  
DOI:
中文关键词:  喹硫平;奥氮平;精神分裂症
英文关键词:Quetiapine;Olanzapine;Schizophrenia;Clinical research
作者单位
徐炳聪,谢穗峰,蔡莉丽 广州市民政局精神病院,广东广州 510430 
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中文摘要:
      [摘要] 目的 探讨喹硫平联合奥氮平治疗精神分裂症的临床疗效。 方法 选取 2018 年 1 ~ 9 月本院精神分裂症患者 60 例,依据随机数字表法分为单奥组和喹奥组,每组 30 例,单奥组给予奥氮平治疗,喹奥组在此基础上给予喹硫平治疗,比较两组临床疗效。 结果 单奥组和喹奥组治疗后各项阳性与阴性症状量表(PANSS)评分明显低于治疗前,喹奥组治疗后各项 PANSS 评分明显低于单奥组,差异有统计学意义(P < 0.05);喹奥组治疗有效率明显高于单奥组,差异有统计学意义(P < 0.05);单奥组和喹奥组不良反应率比较,差异无统计学意义(P > 0.05)。 结论 喹硫平联合奥氮平可有效改善精神分裂症患者的阳性与 阴性症状,有利于提高临床疗效,且安全性好,值得临床推广。
英文摘要:
      [Abstract] Objective To discuss the clinical study of quetiapine combined with olanzapine in the treatment of schizophrenia. Methods Sixty patients with schizophrenia in our Hospital were selected from January 2018 to September 2018,all patients were divided into Dan’ao group and Quao group according to the random distribution,30 cases in each group.The Dan’ao group was treated with olanzapine,and the Quao group on the basis was treated with quetiapine.The clinical effects of two groups were compared. Results The positive and negative symptoms scale (PANSS) scores of the Dan’ao group and the Quao group after treatment were significantly lower than those before treatment,and the PANSS scores of the Quao group after treatment were significantly lower than those of the Dan’ao group(P < 0.05),the difference was statistically significant(P < 0.05).The effective rate of treatment of Quao group were significantly higher than those of Danao group,the difference was statistically significant (P < 0.05).There was no significant difference in the rate of adverse reactions between the Danao group and Quao group (P > 0.05). Conclusion Quetiapine combined with olanzapine can effectively improve the positive and negative symptoms of schizophrenia.It is conducive to improving the clinical efficacy and safety,it’s worth for further clinical promotion.
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