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方宁,陈国伟.特布他林联合布地奈德雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效研究[J].中国医药科学,2019,(16):97-99        基金项目:
特布他林联合布地奈德雾化吸入治疗慢性阻塞性肺疾病急性加重期的疗效研究
Efficacy of terbutaline combined with budesonide aerosol inhalation in the treatment of AECOPD
  
DOI:
中文关键词:  特布他林;布地奈德;雾化吸入;慢性阻塞性肺疾病急性加重期
英文关键词:Terbutaline; Budesonide; Atomization inhalation; Acute exacerbation of chronic obstructive pulmonary disease
作者单位
方宁,陈国伟 广东省阳江市阳东区人民医院呼吸感染科,广东阳江 529500 
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中文摘要:
      [摘要] 目的 探讨特布他林联合布地奈德雾化吸入治疗用于慢性阻塞性肺疾病急性加重期(AECOPD)的临床疗效。 方法 选择我院 2015 年 8 月~ 2018 年 7 月收治的慢性阻塞性肺病急性加重期患者 200 例,按随机数字表法分为观察组和对照组各 100 例,对照组患者采用内科常规治疗方法,观察组患者在内科常规治疗方法基础上加用特布他林联合布地奈德雾化吸入治疗。比较两组患者用药 7d 后的治疗效果、血气分析以及肺功能。 结果 观察组患者治疗有效率为 93.0% ,对照组患者治疗有效率为 76.0%,治疗组患者有效率明显高于对照组,差异有统计学意义(P < 0.05);与治疗前比较,治疗后观察组患者动脉氧分压、动脉血二氧化碳分压、第一秒用力呼气量 ( FEV1 ) 、第一秒用力呼气容积占预计值百分比 ( FEV1% 预计值 ) 均明显改善,差异有统计学意义 ( P < 0.05) 。 结论 特布他林联合布地奈德雾化吸入治疗慢性阻塞性肺疾病急性加重期患者可有效改善患者呼吸困难、缺氧等症状,通畅呼吸道,改善肺功能,值得临床推广。
英文摘要:
      [Abstract] Objective To investigate the clinical efficacy of terbutaline combined with budesonide atomized inhalation in the treatment of acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Methods Two hundred patients with AECOPD admitted in our hospital from August 2015 to July 2018 were selected, and all them were divided into observation group and control group by random number table method, 100 patients in each group. The patients in the control group were treated with conventional medical treatment, and the patients in the observation group were treated with atomized inhalation of terbutaline combined with budesonide on the basis of conventional medical treatment. The curative effect of two groups after 7d, blood gas analysis and lung function were compared. Results The effective rate of treatment was 93% in the observation group and 76% in the control group, the effective rate in the treatment group was significantly higher than that in the control group, and the difference was statistically significant (P < 0.05). Compared with before treatment, after treatment, the partial pressure of arterial oxygen, partial pressure of carbon dioxide in arterial blood, forced expiratory volume in the first second (FEV1) and the percentage of forced expiratory volume in the first second (FEV1% predicted value) in the observation group were significantly improved, and the difference was statistically significant (P < 0.05). Conclusion Terbutaline combined with budesonide atomization inhalation in the treatment of patients with acute exacerbation of COPD can effectively improve the symptoms of patients with dyspnea, hypoxia and other symptoms, open the respiratory tract, improve lung function, and is worthy of clinical promotion.
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