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张晓玙.抗肿瘤中药注射剂不良反应回顾性分析与临床合理用药的探讨[J].中国医药科学,2019,(16):87-90        基金项目:
抗肿瘤中药注射剂不良反应回顾性分析与临床合理用药的探讨
Retrospective analysis on ADR by anti-tumor traditional Chinese medicine injections and explore on clinical rational drug use
  
DOI:
中文关键词:  中药注射液;抗肿瘤治疗;药物不良反应;合理用药
英文关键词:TCM injections;Anti-tumor;Adverse drug reactions;Rational medicine use
作者单位
张晓玙 江苏省徐州市贾汪区人民医院药剂科,江苏徐州 221011 
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中文摘要:
      [摘要] 目的 分析我院常用抗肿瘤中药注射剂治疗药物不良反应(ADR)发生情况,并对临床合理用药进行探讨。 方法 对我院 2014 年 1 月~ 2018 年 12 月抗肿瘤中药注射剂治疗药物不良反应的 60 例患者数据报告进行回顾性分析。 结果 60 例 ADR 报告中,老年(> 60 岁)、女性的发生率更高;涉及中药注射剂主要为参麦注射液、艾迪注射液、康莱特注射液和复方苦参注射液;ADR 主要临床表现为过敏样反应、全身性损害、累及心血管系统、消化系统、神经系统、呼吸系统等;ADR 发生时间主要集中在用药 2h 内。 结论 我院抗肿瘤中药注射剂不良反应发生率较高,应重视 ADR 监测,积极采取降低 ADR 发生风险的措施,提高合理用药水平。
英文摘要:
      [Abstract] Objective To analysis the characteristics of adverse drug reactions (ADR) induced by anti-tumor TCM injections,and to explore the Clinical Rational Drug use. Methods Retrospective analysis of 60 patients reports on the treatment of adverse drug reactions by anti-tumor Traditional Chinese Medicine injection from January 2014 to December 2018 in our hospital. Results Among 60 ADR reports,the elderly patients( > 60 years old) and womenhad the highest proportion;The main Chinese Medicine injection agent were Shenmai injection, Aidi injection and Kanglaite injection and compound Kushen injection;The main clinical manifestations of ADR were allergic reaction,systemic damage,involvement of cardiovascular system,digestive system,nervous system,respiratory system,etc.,the time of occurrence mainly concentrated on the day of medication,especially after 2h. Conclusion The incidence of adverse reactions of anti-tumor Chinese herbal injections in our hospital is high,we should pay attention to ADR monitoring,actively take measures to reduce the risk of ADR,and improve the level of rational drug use.
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关键词: 中国医药科学 中国医学 中国医学科学 中华医学 医学杂志 临床医学杂志 医学期刊 中国预防医学 中华预防医学 预防医学杂志 中国药学 药学杂志
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