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于得泓,战艺,石红.雷公藤多甙片联合甲氨喋呤治疗对类风湿关节炎患者红细胞沉降率、C反应蛋白及类风湿因子的影响[J].中国医药科学,2019,(16):84-86        基金项目:
雷公藤多甙片联合甲氨喋呤治疗对类风湿关节炎患者红细胞沉降率、C反应蛋白及类风湿因子的影响
Influence of tripterygium wilfordii polyglycoside tablets combined with methotrexate for erythrocyte sedimentation rate, C-reactive protein and rheumatoid factor in patients with rheumatoid arthritis
  
DOI:
中文关键词:  雷公藤多甙片;甲氨喋呤;类风湿性关节炎;红细胞沉降率;C 反应蛋白
英文关键词:Tripterygium wilfordii polyglycoside tablets; Methotrexate; Rheumatoid arthritis; Erythrocyte sedimentation rate; C-reactive protein
作者单位
于得泓,战艺,石红 牡丹江医学院附属红旗医院,黑龙江牡丹江 157000 
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中文摘要:
      [摘要] 目的 观察分析雷公藤多甙片联合甲氨喋呤治疗对类风湿关节炎患者红细胞沉降率、C 反应蛋白及类风湿因子的影响。 方法 选择 2018 年 2 月~ 2019 年 2 月在我院进行治疗的 118 例类风湿性关节炎患者进行分析,通过随机分组的方法将其分为两组,对照组 59 例与观察组 59 例,对照组采取甲氨蝶呤治疗,研究组采取雷公藤多甙片联合甲氨喋呤治疗,比较两组患者治疗前后的晨僵时间、关节压痛数量、关节肿胀数量、关节疼痛评分、红细胞沉降率、C 反应蛋白、类风湿因子等各项指标。 结果 两组患者治疗前晨僵时间、关节压痛数量、关节肿胀数量、关节疼痛评分比较,差异无统计学意义(P > 0.05),治疗后研究组患者晨僵时间、关节压痛数量、关节肿胀数量、关节疼痛评分等明显优于对照组(P < 0.05);两组患者治疗前红细胞沉降率、C 反应蛋白、类风湿因子等指标比较,差异无统计学意义(P > 0.05),治疗后研究组患者红细胞沉降率、C 反应蛋白、类风湿因子等指标明显低于对照组(P < 0.05)。 结论 对类风湿性关节炎患者采取雷公藤多甙片联合甲氨喋呤治,能有效改善患者的临床症状,减轻炎症反应,提高治疗效果。
英文摘要:
      [Abstract] Objective To observe and analyze the influence of tripterygium wilfordii polyglycoside tablets combined with methotrexate for erythrocyte sedimentation rate, C-reactive protein and rheumatoid factor in patients with rheumatoid arthritis. Methods 118 cases of patients with rheumatoid arthritis and who treated in our hospital from February 2018 to February 2019 were selected for analysis, and the patients were divided into two groups by random grouping methods, which 59 cases in the control group and 59 cases in the observation group. The control group were treated with methotrexate, while the study group were treated with tripterygium wilfordii polyglycoside tablets combined with methotrexate. Then, the morning stiffness time, joint tenderness, joint swelling, joint pain score, erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor and other indexes before and after treatment of two groups of patients were compared. Results The morning stiffness time, joint tenderness, joint swelling and joint pain score before treatment of two groups of patients were compared, with no statistical difference (P > 0.05).After treatment,the morning stiffness time, joint tenderness, joint swelling and joint pain score in the study group were significantly better than those in the control group (P < 0.05).The erythrocyte sedimentation rate, C-reactive protein and rheumatoid factor before treatment of two groups of patients were compared, with no statistical difference (P > 0.05).After treatment, the erythrocyte sedimentation rate, C-reactive protein and rheumatoid factor in the study group were significantly lower than those in the control group (P < 0.05). Conclusion The tripterygium wilfordii polyglycoside tablets combined with methotrexate for patients with rheumatoid arthritis which can effectively improve the clinical symptoms, alleviate inflammation and improve the treatment effect.
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