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刘锡滨.不同药物治疗季节性过敏性鼻炎的疗效及炎性因子的影响[J].中国医药科学,2019,(16):78-80        基金项目:
不同药物治疗季节性过敏性鼻炎的疗效及炎性因子的影响
Comparison of curative effects of different drugs in treatment of seasonal allergic rhinitis and their effects on inflammatory factors
  
DOI:
中文关键词:  季节性过敏性鼻炎;炎性因子;丙酸氟替卡松;酮替芬;免疫球蛋白;白细胞介素
英文关键词:Seasonal allergic rhinitis; Inflammatory factors; Fluticasone propionate; Ketotifen; Immunoglobulin; Interleukin
作者单位
刘锡滨 大庆油田总医院耳鼻喉科十六病区,黑龙江大庆 163001 
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中文摘要:
      [摘要] 目的 比较不同药物治疗季节性过敏性鼻炎的疗效及炎性因子的影响。方法 选择我院于 2018 年1 ~ 10 月收治的季节性过敏性鼻炎患者 94 例,采用电脑随机法将患者划分为观察组与对照组各 47 例,观察组采用丙酸氟替卡松与酮替芬、联合生理盐水喷剂治疗,对照组采用酮替芬+生理盐水喷剂治疗,评价两组患者治疗有效率、评估两组用药后白细胞介素 4(IL-4)、免疫球蛋白 E(Ig E)、血管细胞间黏附分子 -1(sVCAM-1)、肿瘤坏死因子(TNF-α)、干扰素(IFN-γ)水平;评估两组用药后不良反应发生情况。结果观察组治疗总有效率 45 例(95.74%),高于对照组 37 例(78.72%),差异有统计学意义(P < 0.05)。观察组治疗后 IL-4、IgE、sVCAM-1、TNF-α 指标值均低于对照组,观察组 IFN-γ 指标值高于对照组,P < 0.05。 两组用药后不良反应发生率结果比较无统计学意义,P > 0.05。结论 丙酸氟替卡松与酮替芬治疗季节性过敏性鼻炎疗效乐观,改变 IL-4、IgE、sVCAM-1、TNF-α、IFN-γ 炎性因子水平,用药安全性较高。
英文摘要:
      [Abstract] Objective To compare curative effects of different drugs in treatment of seasonal allergic rhinitis and their effects on inflammatory factors. Methods Ninety-four patients with seasonal allergic rhinitis who were treated in our hospital from January 2018 to October 2018 were selected. They were randomly divided into the observation group and the control group according to the computer randomization method, with 47 cases in each group. The observation group was treated with fluticasone propionate, ketotifen combined with normal saline spray. The control group was treated with ketotifen combined with normal saline spray. The effective rates of treatment of two groups were evaluated. Interleukin 4 (IL-4), immunoglobulin E (Ig-E), soluble vascular cell adhesion molecule-1 (sVCAM-1), tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ) contents as well as adverse reactions after medication were evaluated. Results The total effective rate of treatment in the observation group (n=45) was 95.74%, higher than 78.72% in the control group (n=37). The difference was statistically significant (P < 0.05). After treatment, the values of IL-4, IgE, sVCAM-1 and TNF-α in the observation group were lower than those of the control group while the value of IFN-γ was higher. The difference was statistically significant (P < 0.05). The incidence of adverse reactions after medication of two groups showed no statistically significant difference (P > 0.05). Conclusion Fluticasone propionate and ketotifen in treatment of seasonal allergic rhinitis has good curative effects. It can change levels of IL-4, IgE, sVCAM-1, TNF-α, and IFN-γ inflammatory factors and it has relatively high drug safety.
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