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陈波,梁洁.环磷酰胺联合泼尼松在系统性红斑狼疮治疗中的疗效及安全性分析[J].中国医药科学,2019,(16):66-68        基金项目:
环磷酰胺联合泼尼松在系统性红斑狼疮治疗中的疗效及安全性分析
Analysis on curative effects and safety of cyclophosphamide combined with prednisone in treatment of systemic lupus erythematosus
  
DOI:
中文关键词:  系统性红斑狼疮;泼尼松;环磷酰胺;安全性
英文关键词:Systemic lupus erythematosus;Prednisone;Cyclophosphamide;Safety
作者单位
陈波,梁洁 广东省河源市人民医院肾内风湿科,广东河源 517000 
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中文摘要:
      [摘要] 目的 探讨环磷酰胺联合泼尼松在系统性红斑狼疮治疗中的疗效及安全性。 方法 采用随机数字表法将 2014 年 1 月~ 2017 年 12 月本院接收的系统性红斑狼疮患者 58 例分为对照组和观察组,对照组 29例实施泼尼松单一治疗,观察组 29 例实施泼尼松联合环磷酰胺治疗。将两组系统性红斑狼疮患者的临床效果、免疫球蛋白水平、补体水平、血清炎症因子指标、不良反应发生情况进行比较。 结果 观察组系统性红斑狼疮患者的临床总有效率(93.10%)高于对照组,差异有统计学意义(P < 0.05);观察组治疗后的免疫球蛋白水平、补体水平、血清炎症因子指标均显著低于对照组,差异有统计学意义(P < 0.05);两组不良反应发生率比较,差异无统计学意义(P > 0.05)。 结论 环磷酰胺联合泼尼松应用于系统性红斑狼疮患者的治疗中安全有效。
英文摘要:
      [Abstract] Objective To explore curative effects and safety of cyclophosphamide combined with prednisone in treatment of systemic lupus erythematosus. Methods 58 patients with systemic lupus erythematosus who were admitted to our hospital from January 2014 to December 2017 were divided into the control group and the observation group according to the random number table method.29 patients in the control group were treated with prednisonealone while 29 patients in the observation group were treated with prednisone combined with cyclophosphamide.Clinical curative effects,immunoglobulin levels,complement levels,serum inflammatory factor indexes and adverse reactions of patients with systemic lupus erythematosus in two groups were compared. Results The total clinical effective rate(93.10%)of the patients with systemic lupus erythematosus in the observation group was higher than that in the control group,and the difference was statistically significant(P < 0.05).After treatment,immunoglobulin levels,complement levels,serum inflammatory factor indexes in the observation group were significantly lower than those in the control group,and the difference was statistically significant(P < 0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P > 0.05). Conclusion Cyclophosphamide combined with prednisone in treatment of patients with systemic lupus erythematosusis safe and effective.
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