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谢穗峰1,叶芬1,郭月平2,李论1,喻俊3.哌罗匹隆与阿立哌唑治疗精神分裂症对认知功能的影响[J].中国医药科学,2019,(16):17-19        基金项目:
哌罗匹隆与阿立哌唑治疗精神分裂症对认知功能的影响
Effect of perospirone and aripiprazole in treatment of schizophrenia on cognitive function
  
DOI:
中文关键词:  哌罗匹隆;阿立哌唑;精神分裂症;认知功能
英文关键词:Perospirone;Aripiprazole;Schizophrenia;Cognitive function
作者单位
谢穗峰1,叶芬1,郭月平2,李论1,喻俊3 1. 广州市民政局精神病院男一区,广东广州 510430;2. 广州市民政局精神病院男五区, 广东广州 510430;3. 广州市民政局精神病院男二区,广东广州 510430 
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中文摘要:
      [摘要] 目的 比较哌罗匹隆与阿立哌唑治疗精神分裂症对认知功能的影响。 方法 选取 2017 年 6 月~ 2018年 9 月我院新诊断精神分裂症患者 60 例,按随机数字表法分为哌罗匹隆组和阿立哌唑组,每组 30 例。哌罗匹隆组给予哌罗匹隆治疗,阿立哌唑组给予阿立哌唑治疗。于基线期与治疗后采用学习记忆相关的霍普金斯词汇学习测验 - 修订版(HTLV-R)、WMS- Ⅲ空间广度测验(WMS- Ⅲ SST)、简易视觉空间记忆测验 -修订版(BVMT-R)、信息处理速度相关的测试连线测验(TMT)及符号编码(SC)评价患者认知功能。 结果基线期,哌罗匹隆组与阿立哌唑组 HTLV-R 得分、WMS- Ⅲ SST 得分、BVMT-R 得分、TMT 时间及 SC 得分比较,差异无统计学意义(P > 0.05);治疗后,哌罗匹隆组与阿立哌唑组 HTLV-R 得分、WMS- Ⅲ SST 得分、BVMT-R 得分、TMT 时间及 SC 得分比较,差异无统计学意义(P > 0.05)。治疗后,两组 HTLV-R 得分、WMS- Ⅲ SST 得分、BVMT-R 得分及 SC 得分均较基线期显著提高,差异有统计学意义(P < 0.05)。治疗后,两组 TMT 时间均较基线期显著降低,差异有统计学意义(P < 0.05)。 结论 哌罗匹隆与阿立哌唑在改善精神分裂症患者认知功能均具有相似的特性,效果相当。
英文摘要:
      [Abstract] Objective To compare effects of perospirone and aripiprazole in treatment of schizophrenia on cognitive function. Methods 60 patients who were newly diagnosed as schizophrenia in our hospital from June 2017 to September 2018 were selected.According to the random number table method,they were divided into the perospirone group and the aripiprazole group,with 30 cases in each group.The perospirone group was treated with perospirone while the aripiprazole group was treated with aripiprazole.Hopkins Vocabulary Learning Test-Revised Edition(HTLV-R),WMS- Ⅲ Spatial Span Test(WMS- Ⅲ SST)and Brief Visuospatial Memory Test Revised Edition(BVMT)related to learning and memory,Trail Making Test(TMT)and symbol coding(SC)related to information processing speed were used to evaluate cognitive functions of patients at baseline and after treatment. Results At baseline,there was no statistically significant difference in HTLV-R score,WMS- Ⅲ SST score,BVMT-R score,TMT time and SC score between the piperpirone group and the aripiprazole group(P > 0.05).After treatment,there was no statistically significant difference in HTLV-R score,WMS- Ⅲ SST score,BVMT-R score,TMT time and SC score between the piperazine and the aripiprazole group(P > 0.05).After treatment,the HTLV-R score,WMS- Ⅲ SST score,BVMT-R score and SC score of the two groups were significantly higher than the baseline period.The difference was statistically significant(P < 0.05).After treatment,the TMT time of the two groups was significantly lower than the baseline period,and the difference was statistically significant (P < 0.05). Conclusion Peripirone and aripiprazole have similar characteristics in improving cognitive function in patients with schizophrenia and the curative effect is comparable.
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