中国医药科学杂志欢迎您.   今天是:        
郑仕杰1,于园园2,周敬群1,杨维华1,黄迪1,蔡金丹1,吕建峰1▲.替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死术后患者生存质量的随访研究[J].中国医药科学,2019,(16):9-12        基金项目:湖北省宜昌市医疗卫生科研项目(A-17-301-19)
替格瑞洛与氯吡格雷对急性ST段抬高型心肌梗死术后患者生存质量的随访研究
Follow-up study on quality of life of patients with acute ST segment elevation myocardial infarction after operation by tigreglio and clopidogrel
  
DOI:
中文关键词:  替格瑞洛;氯吡格雷;心肌梗死;生存质量
英文关键词:Ticagrelor;Clopidogrel;Myocardial infarction;Quality of life
作者单位
郑仕杰1,于园园2,周敬群1,杨维华1,黄迪1,蔡金丹1,吕建峰1▲ 1. 三峡大学附属仁和医院心血管内科,湖北宜昌 443000;2. 宁夏医科大学总医院急诊科,宁夏银川 750004 
摘要点击次数: 6
全文下载次数: 10
中文摘要:
      [摘要] 目的 研究替格瑞洛与氯吡格雷对急性 ST 段抬高型心肌梗死术后患者生存质量的影响。 方法 选择2017 年 1 月~ 2018 年 1 月急性 ST 段抬高型心肌梗死患者 218 例,随机分为对照组和实验组,每组 109 例。实验组患者口服替格瑞洛和阿司匹林肠溶片,对照组患者口服氯吡格雷和阿司匹林肠溶片。分别于术前、术后 12 个月向患者发放 SAQ 量表,对患者生存质量予以评估;同时观察两组患者术后 12 个月 MACCE,分析患者术后生存质量的变化及影响因素。 结果 两组患者术后 12 个月 MACCE 比较,实验组低于对照组,差异有统计学意义(P < 0.05)。高龄、血管病变严重、心绞痛症状发作频率、非致死性脑卒中是影响术后生存质量的独立危险因素。两组患者术后 12 个月,SAQ 各项评分均高于术前(P < 0.05),且组间比较显示,实 验组评分高于对照组(P < 0.05)。 结论 替格瑞洛在经皮冠状动脉介入术后患者中 MACCE 发生率低于氯吡格雷,且生存质量高于氯吡格雷;高龄、血管狭窄严重、心绞痛症状发作频率及非致死性脑卒中是影响患者术后生存质量的风险因素。
英文摘要:
      [Abstract] Objective To study the effects of ticagrelor and clopidogrel on quality of life in patients with acute STsegment elevation myocardial infarction. Methods 218 cases of acute ST-segment elevation myocardial infarction from January 2017 to January 2018 were randomly divided into control group and experimental group,109 cases in each group.The experimental group was treated with tegrilol and aspirin enteric-coated tablets,while the control group was treated with clopidogrel and aspirin enteric-coated tablets.The SAQ health survey scale was issued to patients before and 12 months after surgery to evaluate the quality of life.Meanwhile,major adverse cardiac and cerebrovascular events were observed 12 months after operation in both groups,and the changes of quality of life and influencing factors were analyzed. Results Compared with the control group,the MACCE in the experimental group was lower than that in the control group 12 months after operation, and the difference was statistically significant (P < 0.05).Age,severe vascular disease,frequency of angina pectoris symptoms and non-fatal stroke are independent risk factors affecting the quality of life after operation.At 12 months after operation,the SAQ scores of the two groups were higher than those of the control group (P < 0.05),and the comparison between the two groups showed that the SAQ scores of the experimental group were higher than those of the control group (P < 0.05). Conclusion The incidence of MACCE in patients after percutaneous coronary intervention (PCI) is lower than that of clopidogrel,and the quality of life is higher than that of clopidogrel.Age,severe vascular stenosis,frequency of angina symptoms and non-fatal stroke are risk factors affecting the quality of life of patients after PCI.
查看全文  查看/发表评论  下载PDF阅读器
关闭
关键词: 中国医药科学 中国医学 中国医学科学 中华医学 医学杂志 临床医学杂志 医学期刊 中国预防医学 中华预防医学 预防医学杂志 中国药学 药学杂志
药理杂志 中国中医 中医杂志 中华中医药 中医药杂志 中国医疗 医疗器械杂志 中国中西医结合 中国医药 医药杂志 医药期刊 医药论文 医学论文 科研论文 职称论文
function PdfOpen(url){ var win="toolbar=no,location=no,directories=no,status=yes,menubar=yes,scrollbars=yes,resizable=yes"; window.open(url,"",win); } function openWin(url,w,h){ var win="toolbar=no,location=no,directories=no,status=no,menubar=no,scrollbars=yes,resizable=no,width=" + w + ",height=" + h; controlWindow=window.open(url,"",win); } &et=03828B4DB38BB1F384C3EE2F61EE737E8F4429F166EB53E864DED749ACD3F5A3DEDA3C0B83739EC09FA8D88E379674B2571A67549707D4855B390BB129B50255DC226B9C94F75E11B8F8B49D9F531474D854FFC1CFC00E79721372667AFBF17A105F171790AFA3556E4D89BF293D6E1F5FAC77C5042CF49585471F9C20CF9E31E8545ECD8330AE8ECB166972D91409BF9CE2485C1480719B&pcid=&cid=&jid=&yid=B6351343F4791CA3&aid=&vid=&iid=7801E6FC5AE9020C&sid=9CF7A0430CBB2DFD&eid=59906B3B2830C2C5&fileno=20191134&flag=1&is_more=0">