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李博文,何金娜.精神分裂症患者认知功能损害的影响因素分析[J].中国医药科学,2019,(9):247-250        基金项目:
精神分裂症患者认知功能损害的影响因素分析
Analysis on influencing factors of cognitive function impairmen in patients with schizophrenia
  
DOI:
中文关键词:  精神分裂症;认知功能;可重复性成套神经心理状态测验量表;影响因素
英文关键词:Schizophrenia; Cognitive function; RBANS; Influencing factors
作者单位
李博文,何金娜 广东省肇庆复退军人医院精神科,广东肇庆 526070 
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中文摘要:
      目的 探讨精神分裂症患者认知功能损害状况及相关影响因素,为精神科干预评估提供科学依据。 方法 选取 2016 年 1 月~ 2017 年 10 月期间在肇庆复退军人医院精神科住院治疗精神分裂症患者 196 例作为观察组和同期同院身体健康精神正常者 196 例作为对照组,采用可重复性成套神经心理状态测验量表(RBANS)对两组的认知功能进行评定,并分析其影响因素。然后对主要影响因素进行多元线性回归分析及Pearson 相关性分析。 结果 两组 RBANS 总分及即刻记忆、视觉广度、言语功能、注意力、延时记忆等维度得分比较差异有统计学意义(P < 0.05);年龄、性别、文化程度、住院次数及临床分型等影响因素与 RBANS评分存在显著性线性相关(P < 0.05),而病程、婚姻状况及职业与 RBANS 评分未见明显线性相关(P >0.05);Pearson 相关性分析显示,年龄、文化程度及住院次数等主要影响因素与精神分裂症患者认知功能存在显著相关性。 结论 精神分裂症患者普遍存在认知功能损害,广大精神科医师在治疗患者阳性症状和阴性症状时,应更多关注和有意识干预其认知功能障碍,以促进患者早日康复。
英文摘要:
      Objective To explore the cognitive function impairment status and related influencing factors in patients with schizophrenia and to provide scientific basis for intervention and evaluation in department of psychiatry. Methods 196 patients with schizophrenia who were hospitalized and treated in department of psychiatry in Zhaoqing Veterans Hospital from January 2016 to October 2017 were selected as the observation group. In the same period, 196 patients with normal mental health were selected as the control group. The cognitive function of the two groups was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) scale and the influencing factors were analyzed. Then the main influencing factors were analyzed by multiple linear regression and Pearson correlation analysis. Results Differences in total score of RBANS, immediate memory, visual span, speech function, attention and delayed memory were statistically significant between the two groups (P < 0.05). Influencing factors such as age, gender, education level, number of hospitalizations and clinical classification were significantly and linearly correlated with RBANS scores (P < 0.05). There was no significant linear correlation between disease duration, marital status, occupation and RBANS score (P > 0.05). Pearson correlation analysis showed that the main influencing factors such as age, education level and hospitalization frequency were significantly correlated with cognitive function in patients with schizophrenia. Conclusion The cognitive function impairment is common in patients with schizophrenia. Psychiatrists should pay more attention to and consciously intervene in their cognitive dysfunction when treating patients with positive and negative symptoms to promote early recovery.
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