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黎润球,何锦添,毛志强.地塞米松和盐酸氨溴索联合鼓室内注射治疗分泌性中耳炎的有效性、安全性评价[J].中国医药科学,2019,(9):74-76        基金项目:
地塞米松和盐酸氨溴索联合鼓室内注射治疗分泌性中耳炎的有效性、安全性评价
Evaluation on efficacy and safety of dexamethasone and ambroxol hydrochloride combined with intratympanic injection in the treatment of secretory otitis media
  
DOI:
中文关键词:  分泌性中耳炎;地塞米松;盐酸氨溴索;鼓室内注射;纯音听阈
英文关键词:Secretory otitis media; Dexamethasone; Ambroxol hydrochloride; Intratympanic injection; Pure tone threshold
作者单位
黎润球,何锦添,毛志强 广东省东莞市人民医院耳鼻喉科,广东东莞 523059 
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中文摘要:
      目的 评价鼓室内联合注射地塞米松、盐酸氨溴索治疗分泌性中耳炎的有效性、安全性。 方法 将我院 2016 年 10 月 ~ 2017 年 12 月收治的 110 例分泌性中耳炎患者随机分为对照组和研究组,予以对照组地塞米松鼓室内注射治疗,予以研究组地塞米松和盐酸氨溴索联合鼓室内注射治疗,比较两组患者治疗前后的纯音听阈测定(0.5kHz、1.0kHz、2.0kHz)结果、血清炎性因子(IL-5、IL-8、IL-1β)的表达水平、疾病整体治疗效果和不良反应发生情况。 结果 两组治疗前的纯音听阈测定结果、血清炎性因子 IL-5、IL-8、IL-1β 的表达水平检测结果比较差异均无统计学意义(P > 0.05),研究组治疗后各频率的纯音听阈测定结果均较高于对照组(P < 0.05),血清炎性因子 IL-5、IL-8、IL-1β 的表达水平均低于对照组(P < 0.05),临床治疗总有效率为 96.36%,高于对照组的 85.45%(P < 0.05),不良反应发生率为 5.45%,与对照组的 3.64% 比较差异无统计学意义(P> 0.05)。 结论 盐地塞米松、盐酸氨溴索联合鼓室内注射治疗分泌性中耳炎,疗效确切,安全性较高。
英文摘要:
      Objective To evaluate the efficacy and safety of intratympanic injection combined with dexamethasone and ambroxol hydrochloride in the treatment of secretory otitis media. Methods According to the touching ball method, 110 patients with secretory otitis media who were admitted to our hospital from October 2016 to December 2017 were randomly divided into the control group and the study group. The control group was treated with dexamethasone combined with intratympanic injection while the study group was treated with dexamethasone and ambroxol hydrochloride combined with intratympanic injection. The results of pure tone threshold measurement (0.5 kHz, 1.0 kHz, 2.0 kHz), expression levels of serum inflammatory factors (IL-5, IL-8, IL-1β), overall curative effects and adverse reactions of the two groups before and after treatment were compared. Results There were no statistically significant differences in the results of pure tone threshold measurement and expression levels of serum inflammatory factors such as IL-5, IL-8 and IL-1β before treatment (P > 0.05). After treatment, the pure tone auditory threshold of each frequency of the study group was higher than that of the control group (P < 0.05). The expression levels of serum inflammatory factors such as IL-5, IL-8 and IL-1β of the study group were lower than those of the control group (P < 0.05). The total clinical effective rate of the study group was 96.36%, which was higher than that of the control group 85.45% (P < 0.05). The incidence of adverse reactions of the study group was 5.45%, and that of the control group was 3.64%. There was no statistically significant difference between two groups (P> 0.05). Conclusion Dexamethasone and ambroxol hydrochloride combined with intratympanic injection in the treatment of secretory otitis media have accurate curative effects and relatively high safety
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