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郑瑞如1,马杰生2.优泌乐50联合二甲双胍片治疗2型糖尿病的效果分析[J].中国医药科学,2019,(9):55-57        基金项目:
优泌乐50联合二甲双胍片治疗2型糖尿病的效果分析
Analysis on curative effect of HumalogMix 50 combined with Metformin Tablets in the treatment of type 2 diabetes mellitus
  
DOI:
中文关键词:  2 型糖尿病;优泌乐 50;二甲双胍;胰岛素;低血糖
英文关键词:Type 2 diabetes mellitus;HumalogMix 50;Metformin;Insulin;Hypoglycemia
作者单位
郑瑞如1,马杰生2 1. 广东省汕头市潮南民生医院内分泌科,广东汕头 515100;2. 广东省汕头市潮南民生医院呼吸内科,广东汕头 515100 
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中文摘要:
      目的 观察优泌乐 50 联合二甲双胍片在 2 型糖尿病患者上的临床应用效果。 方法 随机选取 2016年 6 月~ 2018 年 6 月我院内分泌科收治的 150 例 2 型糖尿病患者,按照随机数字表法分为观察组和对照组,观察组于餐前 10min 即刻皮下注射优泌乐 50,对照组注射优泌乐 25,方法同观察组,两组均服用二甲双胍缓释片 0.5g/ 次,2 次 /d,治疗并观察 3 个月。 结果 两组患者经治疗,空腹血糖及餐后 2h 血糖值都出现了不同程度的下降,且较治疗前下降明显(P < 0.05);观察组患者在治疗后的空腹血糖及餐后 2h 血糖值明显低于对照组(P < 0.05);治疗后两组患者的 C 肽水平都较治疗前上升,且同对照组相比,观察组升高地更明显,差异有统计学意义(P < 0.05);在治疗时,对照组低血糖事件的发生率为 9.3%,同观察组的 8.0% 相比 差异无统计学意义(P > 0.05)。 结论 优泌乐 50 联合二甲双胍对 2 型糖尿病的控制血糖效果较好,同时不增加低血糖事件的发生风险,具有较好的安全性,因此值得临床应用和推广。
英文摘要:
      Objective To observe the clinical application effect of HumalogMix 50 combined with metformin tablets in patients with type 2 diabetes mellitus. Methods One hundred and fifty patients with type 2 diabetes mellitus who were admitted and treated in the department of endocrinology of our hospital from June 2016 to June 2018 were randomly selected.They were divided into observation group and control group according to therandom number table method.The observation group was subcutaneously injected with HumalogMix 50 at ten minutes before meals while the control group was injected with HumalogMix 25 at ten minutes before meals.Both groups were given sustainedrelease metformin tablets for 0.5g/time and 2 times/day.They were treated and observed for 3 months. Results After treatment,fasting and 2-hour postprandial blood glucose in both groups were decreased,which were significantly lower than those before treatment(P < 0.05).The fasting blood glucose and 2-hour postprandial blood glucose in the observation group were significantly lower than those in the control group(P < 0.05).The C-peptide level after treatment in two groups were both improved compared with that before treatment.The increase in the observation group was more significant than the control group.The difference was statistically significant(P < 0.05).The incidence rate of hypoglycemic events during treatment in the control group and the observation group were respectively 9.3%and 8.0%.The comparative difference had no statistical significance(P > 0.05). Conclusion HumalogMix 50 combined with metformin has a better effect on controlling blood sugar in type 2 diabetes mellitus,which does not increase the risk of hypoglycemic events.It has higher safety and it is worthy of clinical promotion and application.
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